Essential roles of COUP-TFII in Leydig cell differentiation and male fertility.
Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII; also known as NR2F2), is an orphan nuclear receptor of the steroid/thyroid hormone receptor superfamily.COUP-TFII-null mice die Cornhole during the early embryonic development due to angiogenesis and cardiovascular defects.To circumvent the early embryonic lethality and investi